Precision Genetic Model of Neurovascular Unit to Study Alzheimer Disease
Although scientists realize that understanding how to keep blood vessels in the brain healthy may offer new ways to treat Alzheimer disease, a big challenge is that there are not many methods to study brain blood vessels that translate to human physiology. We have developed a method to grow functional three dimensional human blood vessels in the test tube using “tissue engineering” technology and aim now to use this technology to make brain blood vessels using Alzheimer disease patient cells. These disease-like vessels will be used to rapidly test questions about Alzheimer disease pathophysiology and assist in the development of therapeutics.
This project was funded in 2019.