Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology
A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. We have identified an A-beta oligomer-specific targeting site, which exclusively detects A-beta oligomers in the brains and spinal fluids of Alzheimer’s disease patients. Since we only found A-beta oligomers with our targeting site in the brains of Alzheimer’s disease patients, it is possible that we have defined a targeting site specific to the A-beta oligomers that cause disease. We will exploit this new knowledge and our unique tools to learn how toxic A-beta oligomers spread from region-to-region in the brain causing disease. This knowledge is critical for the development of therapeutics to block the spread of neurodegeneration in the brain.
Neil Cashman, Cheryl Wellington, Ging-Yuek Hsiung, Weihong Song
In December 2013 four organizations came together to develop the British Columbia Alzheimer’s Research Award Program. Brain Canada, the Michael Smith Foundation for Health Research (MSFHR), Genome British Columbia (Genome BC), and The Pacific Alzheimer Research Foundation (PARF) put together a $7.5 million fund to seek solutions to Alzheimer’s disease and related dementias. This was one of the projects being awarded a grant. > Learn more…