Locally produced brain insulin in memory and Alzheimer’s disease: A multi-disciplinary approach to a key question
One percent of Alzheimer’s disease is the early-onset type that runs in families. Extensive studies of these ultra-rare forms of Alzheimer’s disease have revealed the genes that cause them. On the other hand, the most common forms of Alzheimer’s disease are surprisingly understudied and poorly understood at the level required for therapeutic intervention. However, it is clear from population levels studies that there are important links between Alzheimer’s disease and obesity, altered fat metabolism, diabetes and insulin. Interestingly, there have been many reports over the years that the brain actually produces a small amount of insulin. Here, we will test the hypothesis that insulin produced in the brain is a critical factor for the survival and function of brain cells in the context of both a genetic change that increases Alzheimer’s risk and a diet that increases Alzheimer’s risk. Our studies are likely to impact our understanding of Alzheimer’s disease, potentially revealing a path to a cure.
James Johnson, Paul Pavlidis, Shernaz Bamji
In December 2013 four organizations came together to develop the British Columbia Alzheimer’s Research Award Program. Brain Canada, the Michael Smith Foundation for Health Research (MSFHR), Genome British Columbia (Genome BC), and The Pacific Alzheimer Research Foundation (PARF) put together a $7.5 million fund to seek solutions to Alzheimer’s disease and related dementias. This was one of the projects being awarded a grant. > Learn more…